Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Kumpf VJ, Holland EG. We have found the lower dose to be better tolerated in the second half of gestation. Either increases effects of the other by pharmacodynamic synergism. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . LBW = Lean body weight in kg. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. LBW = Lean body weight in kg. Use Caution/Monitor. https://www.uptodate.com/ (Requires subscription). Use alternatives if available. Use Caution/Monitor. Before using, check this product visually for particles or discoloration. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Parenteral iron dextran therapy. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Med J Aust. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Volume of iron product required = 25 mL. Use Caution/Monitor. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Reactions have occurred following the first dose or subsequent doses of Venofer. 1982;13(4):309-21. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. MISSED DOSE: It is important to get each dose of this medication as scheduled. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Dosing Administration & Considerations . Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Avoid or Use Alternate Drug. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Applies only to oral form of both agents. Applies only to oral form of both agents. Fatal reactions have followed the test dose of iron dextran injection. Applies only to oral form of both agents. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. 1970;100(7):301303. This cost includes the fee charged by the pharmacy. Avoid or Use Alternate Drug. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Medicinal forms Mode of Administration: Administer Venofer only intravenously by slow injection or by infusion. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. Applies only to oral form of both agents. Use Caution/Monitor. Accessed: 4/12/2011. Dosage Calculator - [100% Free] - Calculators.io If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. This calculator will help pinpoint potential causes of anemia based on Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Iron Deficit - Multi-Calc - GlobalRPH - Medical Calculators, Clinicians The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Minor (1)iron sucrose, benazepril. Applies only to oral form of both agents. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. 1998 Feb;25(1):65-8. Anemia; 2015: 763576. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Included in the iron dextran package insert. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. [. Max Dose. Use Caution/Monitor. Venofer Dosing and Administration Applies only to oral form of both agents. We'll do this entirely for free, as long as the calculator has applications for women's health. 2010; 193(9):525-32. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Interaction only with oral iron administration. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Your list will be saved and can be edited at any time. In the text below the tool there is more information on how the iron deficit is calculated. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Applies only to oral form of both agents. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. Kumpf VJ. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. DailyMed - VENOFER- iron sucrose injection, solution This site contains information for licensed healthcare professionals in the United States. Iron Deficiency Calculator - MDApp Applies only to oral form of both agents. Do not administer Venofer to patients with iron overload. STORAGE: Consult the product instructions and your pharmacist for storage details. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. . Use Caution/Monitor. This document does not contain all possible drug interactions. Separate by 2 hr. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Use Caution/Monitor. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Use Caution/Monitor. Applies only to oral form of both agents. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Applies only to oral form of both agents. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Your doctor will do laboratory tests to monitor your response. Applies only to oral form of both agents. 1995 Mar-Apr;11(2):163-8. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. This topic . Deferoxamine chelates iron. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). Use Caution/Monitor. If we don't have the calculator you need then tell us the details and we'll make it for you. Most In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Venofer may cause clinically significant hypotension. Anemias. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Minor/Significance Unknown. Ganzoni AM. Applies only to oral form of both agents. Applies only to oral form of both agents. Drug Des Devel Ther; 5: 5160. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). FERAHEME vs Venofer (iron sucrose) - Feraheme Burns DL, Mascioli EA, Bistrian BR. Applies only to oral form of both agents. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Use Caution/Monitor. 1) Ganzoni AM. Modify Therapy/Monitor Closely. This site complies with the HONcode standard for trust- worthy health information: verify here. 1970; 100(7):301-3. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Comparable efficacy to that of IV iron sucrose. Aranesp (darbepoetin alfa) | Dosing Considerations Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Dosing: (a) Divide calculated total cumulate dose . Minor/Significance Unknown. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. PDF PRODUCT MONOGRAPH - pdf.hres.ca Use Caution/Monitor. Iron sucrose: 20 mg/mL. Last updated on Jun 1, 2022. Avoid or Use Alternate Drug. iron sucrose, benazepril. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Applies only to oral form of both agents. Use Caution/Monitor. Minor/Significance Unknown. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Modify Therapy/Monitor Closely. Manage and view all your plans together even plans in different states. Venofer (iron sucrose) dosing, indications, interactions, adverse Most Contact the applicable plan Applies only to oral form of both agents. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion.
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